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Structural Genomics and Drug Discovery

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Cover of 'Structural Genomics and Drug Discovery'

Table of Contents

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    Book Overview
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    Chapter 1 Data Management in the Modern Structural Biology and Biomedical Research Environment
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    Chapter 2 Structural Genomics of Human Proteins
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    Chapter 3 Target Selection for Structural Genomics of Infectious Diseases
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    Chapter 4 Selecting Targets from Eukaryotic Parasites for Structural Genomics and Drug Discovery
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    Chapter 5 High-throughput cloning for biophysical applications.
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    Chapter 6 Expression and solubility testing in a high-throughput environment.
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    Chapter 7 Protein Production for Structural Genomics Using E. coli Expression
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    Chapter 8 Eukaryotic Expression Systems for Structural Studies
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    Chapter 9 Automated Cell-Free Protein Production Methods for Structural Studies
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    Chapter 10 Parallel Protein Purification
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    Chapter 11 Oxidative Refolding from Inclusion Bodies
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    Chapter 12 High-Throughput Crystallization Screening
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    Chapter 13 Screening Proteins for NMR Suitability
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    Chapter 14 Salvage or Recovery of Failed Targets by In Situ Proteolysis
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    Chapter 15 Salvage of Failed Protein Targets by Reductive Alkylation
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    Chapter 16 Salvage or Recovery of Failed Targets by Mutagenesis to Reduce Surface Entropy
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    Chapter 17 Data collection for crystallographic structure determination.
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    Chapter 18 Structure Determination, Refinement, and Validation
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    Chapter 19 Virtual high-throughput ligand screening.
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    Chapter 20 Ligand Screening Using Fluorescence Thermal Shift Analysis (FTS)
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    Chapter 21 Ligand Screening Using Enzymatic Assays
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    Chapter 22 Ligand Screening Using NMR
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    Chapter 23 Screening Ligands by X-ray Crystallography
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    Chapter 24 Case study-structural genomics and human protein kinases.
Attention for Chapter 5: High-throughput cloning for biophysical applications.
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Citations

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Chapter title
High-throughput cloning for biophysical applications.
Chapter number 5
Book title
Structural Genomics and Drug Discovery
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-4939-0354-2_5
Pubmed ID
Book ISBNs
978-1-4939-0353-5, 978-1-4939-0354-2
Authors

Kwon K, Peterson SN, Keehwan Kwon, Scott N. Peterson, Kwon, Keehwan, Peterson, Scott N.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 33%
Student > Postgraduate 1 17%
Student > Doctoral Student 1 17%
Student > Master 1 17%
Unknown 1 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 33%
Agricultural and Biological Sciences 2 33%
Social Sciences 1 17%
Unknown 1 17%