| Title |
Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats
|
|---|---|
| Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, February 2001
|
| DOI | 10.1007/s002100000360 |
| Pubmed ID | |
| Authors |
Maria Paola Germanò, Valeria D'Angelo, Maria Rita Mondello, Simona Pergolizzi, Francesco Capasso, Raffaele Capasso, Angelo A. Izzo, Nicola Mascolo, Rita De Pasquale |
| Abstract |
The effect of cannabinoid drugs (i.p.) on cold/restraint stress-induced gastric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55,212-2, 0.1-1 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB1 receptor antagonist SR141716A, but not by the cannabinoid CB2 receptor antagonist SR144528. These results indicate that the antiulcer effect of the cannabinoid receptor agonist WIN 55,212-2 is mediated by cannabinoid CB1 receptors. |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Germany | 1 | 4% |
| Unknown | 23 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 16% |
| Student > Bachelor | 4 | 16% |
| Student > Doctoral Student | 3 | 12% |
| Student > Master | 3 | 12% |
| Professor | 2 | 8% |
| Other | 6 | 24% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 20% |
| Medicine and Dentistry | 5 | 20% |
| Psychology | 3 | 12% |
| Nursing and Health Professions | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 3 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2012.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#438
of 1,892 outputs
Outputs of similar age
#26,134
of 113,958 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#2
of 13 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,892 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 113,958 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.