Title |
Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats
|
---|---|
Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, February 2001
|
DOI | 10.1007/s002100000360 |
Pubmed ID | |
Authors |
Maria Paola Germanò, Valeria D'Angelo, Maria Rita Mondello, Simona Pergolizzi, Francesco Capasso, Raffaele Capasso, Angelo A. Izzo, Nicola Mascolo, Rita De Pasquale |
Abstract |
The effect of cannabinoid drugs (i.p.) on cold/restraint stress-induced gastric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55,212-2, 0.1-1 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB1 receptor antagonist SR141716A, but not by the cannabinoid CB2 receptor antagonist SR144528. These results indicate that the antiulcer effect of the cannabinoid receptor agonist WIN 55,212-2 is mediated by cannabinoid CB1 receptors. |
Mendeley readers
Geographical breakdown
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Unknown | 23 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 16% |
Student > Doctoral Student | 3 | 12% |
Student > Master | 3 | 12% |
Professor | 2 | 8% |
Other | 6 | 24% |
Unknown | 3 | 12% |
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Other | 2 | 8% |
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