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Mendeley readers
Attention Score in Context
| Title |
Prolonged Survival and Remyelination After Hematopoietic Cell Transplantation in the Twitcher Mouse
|
|---|---|
| Published in |
Science, September 1984
|
| DOI | 10.1126/science.6382609 |
| Pubmed ID | |
| Authors |
Andrew M. Yeager, Susan Brennan, Carol Tiffany, Hugo W. Moser, George W. Santos |
| Abstract |
The twitcher mouse is an animal model of galactosylceramidase deficiency (Krabbe's disease), a human sphingolipidosis. The effects of hematopoietic cell transplantation as potential enzyme replacement therapy were examined in the twitcher mouse. Survival in twitcher mice with transplants was significantly prolonged and was associated with gradual repair of demyelination in peripheral nerves. In contrast, there was no improvement in the neurodegenerative process in the central nervous system after transplantation. These observations indicate that cellular transplantation may effectively provide in vivo enzyme replacement for the peripheral manifestations of genetic storage diseases. Strategies to perturb the blood-brain barrier may be necessary for enzyme replacement to be therapeutic in diseases with central nervous system manifestations. |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Unknown | 26 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 19% |
| Student > Bachelor | 5 | 19% |
| Researcher | 5 | 19% |
| Student > Postgraduate | 3 | 11% |
| Professor | 2 | 7% |
| Other | 4 | 15% |
| Unknown | 3 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 26% |
| Medicine and Dentistry | 6 | 22% |
| Agricultural and Biological Sciences | 4 | 15% |
| Neuroscience | 4 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 4 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2022.
All research outputs
#7,741,906
of 23,544,006 outputs
Outputs from Science
#48,611
of 78,649 outputs
Outputs of similar age
#2,524
of 9,146 outputs
Outputs of similar age from Science
#49
of 114 outputs
Altmetric has tracked 23,544,006 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 78,649 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 63.3. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 9,146 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.