| Title |
Plant versus animal based diets and insulin resistance, prediabetes and type 2 diabetes: the Rotterdam Study
|
|---|---|
| Published in |
European Journal of Epidemiology, June 2018
|
| DOI | 10.1007/s10654-018-0414-8 |
| Pubmed ID | |
| Authors |
Zhangling Chen, Maria Geertruida Zuurmond, Niels van der Schaft, Jana Nano, Hanneke Anna Hendrikje Wijnhoven, Mohammad Arfan Ikram, Oscar Horacio Franco, Trudy Voortman |
| Abstract |
Vegan or vegetarian diets have been suggested to reduce type 2 diabetes (T2D) risk. However, not much is known on whether variation in the degree of having a plant-based versus animal-based diet may be beneficial for prevention of T2D. We aimed to investigate whether level of adherence to a diet high in plant-based foods and low in animal-based foods is associated with insulin resistance, prediabetes, and T2D. Our analysis included 6798 participants (62.7 ± 7.8 years) from the Rotterdam Study (RS), a prospective population-based cohort in the Netherlands. Dietary intake data were collected with food-frequency questionnaires at baseline of three sub-cohorts of RS (RS-I-1: 1989-1993, RS-II-1: 2000-2001, RS-III-1: 2006-2008). We constructed a continuous plant-based dietary index (range 0-92) assessing adherence to a plant-based versus animal-based diet. Insulin resistance at baseline and follow-up was assessed using homeostasis model assessment of insulin resistance (HOMA-IR). Prediabetes and T2D were collected from general practitioners' records, pharmacies' databases, and follow-up examinations in our research center until 2012. We used multivariable linear mixed models to examine association of the index with longitudinal HOMA-IR, and multivariable Cox proportional-hazards regression models to examine associations of the index with risk of prediabetes and T2D. During median 5.7, and 7.3 years of follow-up, we documented 928 prediabetes cases and 642 T2D cases. After adjusting for sociodemographic and lifestyle factors, a higher score on the plant-based dietary index was associated with lower insulin resistance (per 10 units higher score: β = -0.09; 95% CI: - 0.10; - 0.08), lower prediabetes risk (HR = 0.89; 95% CI: 0.81; 0.98), and lower T2D risk [HR = 0.82 (0.73; 0.92)]. After additional adjustment for BMI, associations attenuated and remained statistically significant for longitudinal insulin resistance [β = -0.05 (- 0.06; - 0.04)] and T2D risk [HR = 0.87 (0.79; 0.99)], but no longer for prediabetes risk [HR = 0.93 (0.85; 1.03)]. In conclusion, a more plant-based and less animal-based diet may lower risk of insulin resistance, prediabetes and T2D. These findings strengthen recent dietary recommendations to adopt a more plant-based diet.Clinical Trial Registry number and website NTR6831, http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=6831 . |
X Demographics
The data shown below were collected from the profiles of 77 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 18% |
| Spain | 8 | 10% |
| United Kingdom | 4 | 5% |
| Argentina | 2 | 3% |
| France | 2 | 3% |
| Netherlands | 2 | 3% |
| Mexico | 1 | 1% |
| Thailand | 1 | 1% |
| Saudi Arabia | 1 | 1% |
| Other | 7 | 9% |
| Unknown | 35 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 61 | 79% |
| Practitioners (doctors, other healthcare professionals) | 9 | 12% |
| Scientists | 7 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 420 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 420 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 81 | 19% |
| Student > Master | 59 | 14% |
| Student > Ph. D. Student | 29 | 7% |
| Researcher | 23 | 5% |
| Student > Doctoral Student | 14 | 3% |
| Other | 52 | 12% |
| Unknown | 162 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 83 | 20% |
| Nursing and Health Professions | 68 | 16% |
| Agricultural and Biological Sciences | 25 | 6% |
| Biochemistry, Genetics and Molecular Biology | 24 | 6% |
| Chemistry | 5 | 1% |
| Other | 39 | 9% |
| Unknown | 176 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 123. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
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#347,177
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Outputs from European Journal of Epidemiology
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Outputs of similar age from European Journal of Epidemiology
#1
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