| Chapter title |
Fidelity Variants and RNA Quasispecies
|
|---|---|
| Chapter number | 483 |
| Book title |
Quasispecies: From Theory to Experimental Systems
|
| Published in |
Current topics in microbiology and immunology, November 2015
|
| DOI | 10.1007/82_2015_483 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-923897-5, 978-3-31-923898-2
|
| Authors |
Antonio V. Bordería, Kathryn Rozen-Gagnon, Marco Vignuzzi, Bordería, Antonio V., Rozen-Gagnon, Kathryn, Vignuzzi, Marco |
| Abstract |
By now, it is well established that the error rate of the RNA-dependent RNA polymerase (RdRp) that replicates RNA virus genomes is a primary driver of the mutation frequencies observed in RNA virus populations-the basis for the RNA quasispecies. Over the last 10 years, a considerable amount of work has uncovered the molecular determinants of replication fidelity in this enzyme. The isolation of high- and low-fidelity variants for several RNA viruses, in an expanding number of viral families, provides evidence that nature has optimized the fidelity to facilitate genetic diversity and adaptation, while maintaining genetic integrity and infectivity. This chapter will provide an overview of what fidelity variants tell us about RNA virus biology and how they may be used in antiviral approaches. |
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Mendeley readers
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Demographic breakdown
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|---|---|---|
| Student > Ph. D. Student | 16 | 22% |
| Researcher | 12 | 17% |
| Student > Bachelor | 8 | 11% |
| Student > Master | 6 | 8% |
| Student > Doctoral Student | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 16 | 22% |
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|---|---|---|
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| Veterinary Science and Veterinary Medicine | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 19 | 26% |