| Title |
Multidrug Resistance Proteins (MRPs) and Cancer Therapy
|
|---|---|
| Published in |
The AAPS Journal, April 2015
|
| DOI | 10.1208/s12248-015-9757-1 |
| Pubmed ID | |
| Authors |
Yun-Kai Zhang, Yi-Jun Wang, Pranav Gupta, Zhe-Sheng Chen |
| Abstract |
The ATP-binding cassette (ABC) transporters are members of a protein superfamily that are known to translocate various substrates across membranes, including metabolic products, lipids and sterols, and xenobiotic drugs. Multidrug resistance proteins (MRPs) belong to the subfamily C in the ABC transporter superfamily. MRPs have been implicated in mediating multidrug resistance by actively extruding chemotherapeutic substrates. Moreover, some MRPs are known to be essential in physiological excretory or regulatory pathways. The importance of MRPs in cancer therapy is also implied by their clinical insights. Modulating the function of MRPs to re-sensitize chemotherapeutic agents in cancer therapy shows great promise in cancer therapy; thus, multiple MRP inhibitors have been developed recently. This review article summarizes the structure, distribution, and physiological as well as pharmacological function of MRP1-MRP9 in cancer chemotherapy. Several novel modulators targeting MRPs in cancer therapy are also discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | <1% |
| Unknown | 141 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 22% |
| Student > Master | 18 | 13% |
| Student > Doctoral Student | 16 | 11% |
| Student > Bachelor | 12 | 8% |
| Researcher | 9 | 6% |
| Other | 19 | 13% |
| Unknown | 37 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 23% |
| Agricultural and Biological Sciences | 16 | 11% |
| Medicine and Dentistry | 16 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 11% |
| Neuroscience | 3 | 2% |
| Other | 15 | 11% |
| Unknown | 43 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2015.
All research outputs
#4,185,029
of 22,854,458 outputs
Outputs from The AAPS Journal
#210
of 1,287 outputs
Outputs of similar age
#53,234
of 263,866 outputs
Outputs of similar age from The AAPS Journal
#10
of 41 outputs
Altmetric has tracked 22,854,458 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,287 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,866 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.