Title |
Multidrug Resistance Proteins (MRPs) and Cancer Therapy
|
---|---|
Published in |
The AAPS Journal, April 2015
|
DOI | 10.1208/s12248-015-9757-1 |
Pubmed ID | |
Authors |
Yun-Kai Zhang, Yi-Jun Wang, Pranav Gupta, Zhe-Sheng Chen |
Abstract |
The ATP-binding cassette (ABC) transporters are members of a protein superfamily that are known to translocate various substrates across membranes, including metabolic products, lipids and sterols, and xenobiotic drugs. Multidrug resistance proteins (MRPs) belong to the subfamily C in the ABC transporter superfamily. MRPs have been implicated in mediating multidrug resistance by actively extruding chemotherapeutic substrates. Moreover, some MRPs are known to be essential in physiological excretory or regulatory pathways. The importance of MRPs in cancer therapy is also implied by their clinical insights. Modulating the function of MRPs to re-sensitize chemotherapeutic agents in cancer therapy shows great promise in cancer therapy; thus, multiple MRP inhibitors have been developed recently. This review article summarizes the structure, distribution, and physiological as well as pharmacological function of MRP1-MRP9 in cancer chemotherapy. Several novel modulators targeting MRPs in cancer therapy are also discussed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | <1% |
Unknown | 139 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 22% |
Student > Master | 18 | 13% |
Student > Doctoral Student | 16 | 11% |
Student > Bachelor | 12 | 9% |
Researcher | 9 | 6% |
Other | 16 | 11% |
Unknown | 38 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 33 | 24% |
Agricultural and Biological Sciences | 16 | 11% |
Medicine and Dentistry | 16 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 16 | 11% |
Neuroscience | 3 | 2% |
Other | 12 | 9% |
Unknown | 44 | 31% |