Study by Zhang et al reveals functional crosstalk between classical TAP-dependent MHC complexes and Qa-1 b /HLA-E in tumors with impaired antigen processing machinery. This can dramatically influence efficacy of immune checkpoint blockade. https://t.co/je0
1,956 followers
1,956 followers
Study by Zhang et al reveals functional crosstalk between classical TAP-dependent MHC complexes and Qa-1 b /HLA-E in tumors with impaired antigen processing machinery. This can dramatically influence efficacy of immune checkpoint blockade. https://t.co/lr
5,268 followers
New from the @GeneCollector lab: resistance to anti-PD1 therapy in TAP1 deficient tumors is reversed by co-deletion of Qa-1, and is associated w/ increased CD8+ T cells and decreased tumor-associated neutrophils and CD4+ regulatory T cells: https://t.co/U
776 followers
RT @GeneCollector: Qa-1b is the mouse version of HLA-E. Our study shows that this non-classical HLA modulates resistance to immune checkpo…