Title |
Characterization of Humoral and Cellular Immune Responses Elicited by a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine in Healthy Adults (IPCAVD 001)
|
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Published in |
Journal of Infectious Diseases, November 2012
|
DOI | 10.1093/infdis/jis671 |
Pubmed ID | |
Authors |
Dan H. Barouch, Jinyan Liu, Lauren Peter, Peter Abbink, M. Justin Iampietro, Ann Cheung, Galit Alter, Amy Chung, Anne-Sophie Dugast, Nicole Frahm, M. Juliana McElrath, Holger Wenschuh, Ulf Reimer, Michael S. Seaman, Maria G. Pau, Mo Weijtens, Jaap Goudsmit, Stephen R. Walsh, Raphael Dolin, Lindsey R. Baden |
Abstract |
Adenovirus serotype 26 (Ad26) has been developed as a novel candidate vaccine vector for human immunodeficiency virus type 1 (HIV-1) and other pathogens. The primary safety and immunogenicity data from the Integrated Preclinical/Clinical AIDS Vaccine Development Program (IPCAVD) 001 trial, the first-in-human evaluation of a prototype Ad26 vector-based vaccine expressing clade A HIV-1 Env (Ad26.ENVA.01), are reported concurrently with this article. Here, we characterize in greater detail the humoral and cellular immune responses elicited by Ad26.ENVA.01 in humans. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Kenya | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
France | 1 | 1% |
Unknown | 86 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 22% |
Researcher | 18 | 20% |
Student > Bachelor | 8 | 9% |
Student > Master | 6 | 7% |
Student > Doctoral Student | 3 | 3% |
Other | 7 | 8% |
Unknown | 27 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 19% |
Immunology and Microbiology | 16 | 18% |
Medicine and Dentistry | 14 | 16% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 5 | 6% |
Unknown | 27 | 31% |