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Inhibition of spleen tyrosine kinase as treatment of postoperative ileus

Overview of attention for article published in Gut, December 2012
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Citations

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Title
Inhibition of spleen tyrosine kinase as treatment of postoperative ileus
Published in
Gut, December 2012
DOI 10.1136/gutjnl-2012-302615
Pubmed ID
Authors

Sjoerd H W van Bree, Pedro Julian Gomez-Pinilla, Fleur Suzanne van de Bovenkamp, Martina Di Giovangiulio, Giovanna Farro, Andrea Nemethova, Cathy Cailotto, Wouter J de Jonge, Kevin Lee, Cesar Ramirez-Molina, Dave Lugo, Michael J Skynner, Guy E E Boeckxstaens, Gianluca Matteoli

Abstract

Intestinal inflammation resulting from manipulation-induced mast cell activation is a crucial mechanism in the pathophysiology of postoperative ileus (POI). Recently it has been shown that spleen tyrosine kinase (Syk) is involved in mast cell degranulation. Therefore, we have evaluated the effect of the Syk-inhibitor GSK compound 143 (GSK143) as potential treatment to shorten POI.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 6%
United Kingdom 1 3%
Unknown 29 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 22%
Student > Doctoral Student 5 16%
Student > Ph. D. Student 4 13%
Student > Master 4 13%
Professor > Associate Professor 3 9%
Other 6 19%
Unknown 3 9%
Readers by discipline Count As %
Medicine and Dentistry 13 41%
Agricultural and Biological Sciences 6 19%
Immunology and Microbiology 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 3 9%
Unknown 5 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2012.
All research outputs
#20,176,348
of 22,689,790 outputs
Outputs from Gut
#6,541
of 6,809 outputs
Outputs of similar age
#247,283
of 278,829 outputs
Outputs of similar age from Gut
#41
of 52 outputs
Altmetric has tracked 22,689,790 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,809 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,829 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.