“As the latter linkage results are not explained by common variants, we suggest that rare variants play an important role in human familial longevity.” (APOE is a class of fat metabolizing pathway proteins linked to Alzheimer’s). https://t.co/U5v9WbLoaH
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“In the largest linkage scan thus far performed for human familial longevity, we confirm that the APOE locus is a longevity gene and that additional longevity loci may be identified at 14q11.2, 17q12-q22, and 19p13.3-p13.11.“ https://t.co/U5v9WbLoaH
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“Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in 15 study centers of 11 European countries as part of the Genetics of Healthy Aging (GEHA) project.” https://t.co/U5v9WbLoaH
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“To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported.“ https://t.co/U5v9WbLoaH