Links Zhang: https://t.co/twZJxVPnY9 Church: https://t.co/bWPzSBs55S Both in @ScienceMagazine same day #NephJC book club
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Mali, P., Yang, L., Esvelt, K., Aach, J., Guell, M., DiCarlo, J., Norville, J., & Church, G. (2013). RNA-guided human genome engineering via cas9. 𝘚𝘤𝘪𝘦𝘯𝘤𝘦, 339(6121), 823–826. https://t.co/7UNFz31FKF [27/43]
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Paper #18: https://t.co/zVZDIPE93Y Demonstrated 1) #CRISPRCas gene editing in human cells, 2) multiplexed editing of genomic loci, and 3) proposed that target locus’s chromatin structure and epigenetic state may affect the efficiency of genome editing