Title |
Detection of fecal shedding of rotavirus vaccine in infants following their first dose of pentavalent rotavirus vaccine
|
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Published in |
Vaccine, April 2011
|
DOI | 10.1016/j.vaccine.2011.03.074 |
Pubmed ID | |
Authors |
Catherine Yen, Kathleen Jakob, Mathew D. Esona, Ximara Peckham, John Rausch, Jennifer J. Hull, Susan Whittier, Jon R. Gentsch, Philip LaRussa |
Abstract |
Studies on rotavirus vaccine shedding and its potential transmission within households including immunocompromised individuals are needed to better define the potential risks and benefits of vaccination. We examined fecal shedding of pentavalent rotavirus vaccine (RV5) for 9 days following the first dose of vaccine in infants between 6 and 12 weeks of age. Rotavirus antigen was detected by enzyme immunoassay (EIA), and vaccine-type rotavirus was identified by nucleotide sequencing based on genetic relatedness to the RV5 VP6 gene. Stool from 22 (21.4%) of 103 children contained rotavirus antigen-positive specimens on ≥ 1 post-vaccination days. Rotavirus antigen was detected as early as post-vaccination day 3 and as late as day 9, with peak numbers of shedding on post-vaccination days 6 through 8. Vaccine-type rotavirus was detected in all 50 antigen-positive specimens and 8 of 8 antigen-negative specimens. Nine (75%) of 12 EIA-positive and 1 EIA-negative samples tested culture-positive for vaccine-type rotavirus. Fecal shedding of rotavirus vaccine virus after the first dose of RV5 occurred over a wide range of post-vaccination days not previously studied. These findings will help better define the potential for horizontal transmission of vaccine virus among immunocompromised household contacts of vaccinated infants for future studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 27% |
United Kingdom | 3 | 10% |
Denmark | 1 | 3% |
Canada | 1 | 3% |
Unknown | 17 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 25 | 83% |
Practitioners (doctors, other healthcare professionals) | 3 | 10% |
Scientists | 1 | 3% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 2% |
South Africa | 1 | 2% |
Unknown | 48 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 20% |
Student > Bachelor | 9 | 18% |
Researcher | 6 | 12% |
Student > Master | 6 | 12% |
Other | 5 | 10% |
Other | 7 | 14% |
Unknown | 7 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 42% |
Agricultural and Biological Sciences | 8 | 16% |
Immunology and Microbiology | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Other | 5 | 10% |
Unknown | 9 | 18% |