Title |
Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
|
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Published in |
The Lancet, March 2013
|
DOI | 10.1016/s0140-6736(12)61767-x |
Pubmed ID | |
Authors |
John J Bissler, J Christopher Kingswood, Elżbieta Radzikowska, Bernard A Zonnenberg, Michael Frost, Elena Belousova, Matthias Sauter, Norio Nonomura, Susanne Brakemeier, Petrus J de Vries, Vicky H Whittemore, David Chen, Tarek Sahmoud, Gaurav Shah, Jeremie Lincy, David Lebwohl, Klemens Budde |
Abstract |
Angiomyolipomas are slow-growing tumours associated with constitutive activation of mammalian target of rapamycin (mTOR), and are common in patients with tuberous sclerosis complex and sporadic lymphangioleiomyomatosis. The insidious growth of these tumours predisposes patients to serious complications including retroperitoneal haemorrhage and impaired renal function. Everolimus, a rapamycin derivative, inhibits the mTOR pathway by acting on the mTOR complex 1. We compared the angiomyolipoma response rate on everolimus with placebo in patients with tuberous sclerosis or sporadic lymphanioleiomyomatosis-associated angiomyolipomata. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 31% |
Spain | 1 | 8% |
Serbia | 1 | 8% |
Germany | 1 | 8% |
United Kingdom | 1 | 8% |
Italy | 1 | 8% |
Unknown | 4 | 31% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 62% |
Practitioners (doctors, other healthcare professionals) | 3 | 23% |
Scientists | 2 | 15% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 2 | <1% |
France | 1 | <1% |
Korea, Republic of | 1 | <1% |
United Kingdom | 1 | <1% |
Taiwan | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Poland | 1 | <1% |
Unknown | 271 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 39 | 14% |
Other | 32 | 11% |
Student > Bachelor | 28 | 10% |
Student > Doctoral Student | 24 | 9% |
Student > Master | 23 | 8% |
Other | 79 | 28% |
Unknown | 55 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 133 | 48% |
Agricultural and Biological Sciences | 19 | 7% |
Nursing and Health Professions | 14 | 5% |
Neuroscience | 9 | 3% |
Biochemistry, Genetics and Molecular Biology | 8 | 3% |
Other | 28 | 10% |
Unknown | 69 | 25% |