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Molecular epidemiology of HIV in a cohort of men having sex with men from Istanbul

Overview of attention for article published in Medical Microbiology and Immunology, January 2013
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Title
Molecular epidemiology of HIV in a cohort of men having sex with men from Istanbul
Published in
Medical Microbiology and Immunology, January 2013
DOI 10.1007/s00430-012-0285-7
Pubmed ID
Authors

Dilek Alpsar, Ali Agacfidan, Nadine Lübke, Jens Verheyen, Haluk Eraksoy, Atahan Çağatay, Emel Bozkaya, Rolf Kaiser, Baki Akgül

Abstract

In Turkey, the first HIV/AIDS case was reported in 1985. Since then the number of persons with HIV infection has increased, HIV is getting a public health problem. The aim of this study was to determine HIV-1 subtype diversity, drug resistance and gag cleavage site mutations among 20 HIV-infected men having sex with men from Istanbul, Turkey. The most prevalent subtype was found to be subtype B (50 %), but also the non-B subtypes A1, C and CRF02_AG, CRF03_AB and CRF06_cpx were found. Resistance-associated mutations were found in 6 patients (30 %) with 2/6 patients being therapy-experienced and 4/6 therapy-naïve at the time-point of analysis. In these patients, the nucleoside reverse transcriptase inhibitor (NRTI)-associated resistance mutations M41L, T215C, V75I, T69N, the non-NRTI associated mutations V106I, E138A, K103N and the protease inhibitor associated mutations Q58E and V82I were detected. Two virus strains also presented Gag cleavage site mutations. With increasing numbers of HIV-infected Turkish patients that require anti-retroviral treatment, HIV-1 drug-resistance testing is strongly recommended in order to choose the most active drug combination for therapy to achieve better clinical outcomes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 19%
Student > Master 3 14%
Researcher 3 14%
Professor > Associate Professor 2 10%
Unknown 9 43%
Readers by discipline Count As %
Medicine and Dentistry 4 19%
Biochemistry, Genetics and Molecular Biology 1 5%
Nursing and Health Professions 1 5%
Arts and Humanities 1 5%
Computer Science 1 5%
Other 3 14%
Unknown 10 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2013.
All research outputs
#15,378,098
of 23,815,455 outputs
Outputs from Medical Microbiology and Immunology
#415
of 627 outputs
Outputs of similar age
#179,912
of 287,190 outputs
Outputs of similar age from Medical Microbiology and Immunology
#1
of 3 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 627 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,190 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them