Usually the different parts of the innate immune system all help each other out. This does not seem to be the case with complement... the c3a complement receptor actually stops natural killer cells from entering the tumor! https://t.co/9vvDsAbNGL
In the Feb. issue by Saravanan Nandagopal, Amato J. Giaccia, and colleagues: Activation of the #C3a receptor is shown to impact cytotoxic #NKcell infiltration into the #TME of solid tumors via interactions with the integrin #LFA1. https://t.co/l08cJHkv6d h
C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models https://t.co/bniCDcFiTa
RT @roumenina: C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models https://t.co/oUnuYUTSAe