Title |
Insulin gene therapy for type 1 diabetes mellitus.
|
---|---|
Published in |
Experimental and clinical transplantation official journal of the Middle East Society for Organ Transplantation, April 2015
|
DOI | 10.6002/ect.mesot2014.l67 |
Pubmed ID | |
Authors |
Andrew M Handorf, Hans W Sollinger, Tausif Alam |
Abstract |
Type 1 diabetes mellitus is an autoimmune disease resulting from the destruction of pancreatic β cells. Current treatments for patients with type 1 diabetes mellitus include daily insulin injections or whole pancreas transplant, each of which are associated with profound drawbacks. Insulin gene therapy, which has shown great efficacy in correcting hyperglycemia in animal models, holds great promise as an alternative strategy to treat type 1 diabetes mellitus in humans. Insulin gene therapy refers to the targeted expression of insulin in non-β cells, with hepatocytes emerging as the primary therapeutic target. In this review, we present an overview of the current state of insulin gene therapy to treat type 1 diabetes mellitus, including the need for an alternative therapy, important features dictating the success of the therapy, and current obstacles preventing the translation of this treatment option to a clinical setting. In so doing, we hope to shed light on insulin gene therapy as a viable option to treat type 1 diabetes mellitus. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Côte d'Ivoire | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 85 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 22 | 26% |
Researcher | 9 | 10% |
Student > Master | 9 | 10% |
Student > Ph. D. Student | 7 | 8% |
Student > Doctoral Student | 5 | 6% |
Other | 8 | 9% |
Unknown | 26 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 17% |
Medicine and Dentistry | 14 | 16% |
Agricultural and Biological Sciences | 12 | 14% |
Computer Science | 3 | 3% |
Nursing and Health Professions | 3 | 3% |
Other | 11 | 13% |
Unknown | 28 | 33% |