Title |
Rinsing morcellised bone grafts with bisphosphonate solution prevents their resorption A PROSPECTIVE RANDOMISED DOUBLE-BLINDED STUDY
|
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Published in |
The Bone & Joint Journal, August 2006
|
DOI | 10.1302/0301-620x.88b8.17457 |
Pubmed ID | |
Authors |
U. Kesteris, P. Aspenberg |
Abstract |
During revision total hip replacement using morcellised compacted bone allograft, 16 patients were randomised to receive a graft which had been rinsed in either an ibandronate solution or in saline. Patients were assessed by dual energy x-ray absorptiometry after operation and at 3, 6, 12 and 24 months. A region of interest between the tip of the femoral stem and the distal plastic plug was chosen to measure the changes in bone density over time. The study was double-blinded. In all the control patients the bone density decreased during the first three months and then remained constant at this lower level. A large proportion of the mass of the bone graft was lost. In contrast, all patients with grafts treated with bisphosphonate showed a slight increase in bone density. The difference between the groups was highly significant at all points in time. We conclude that rinsing the graft in a bisphosphonate solution prevents its resorption and may therefore reduce the risk of mechanical failure. The treatment is simple, inexpensive, and appears virtually free of risk. |
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