Title |
G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer’s Disease Mice via CXCR4/SDF-1 Chemotaxis
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Published in |
Molecular Neurobiology, October 2016
|
DOI | 10.1007/s12035-016-0122-x |
Pubmed ID | |
Authors |
Cheng-Chun Wu, I-Fang Wang, Po-Min Chiang, Liang-Chao Wang, Che-Kun James Shen, Kuen-Jer Tsai |
Abstract |
Recent studies reported granulocyte colony-stimulating factor (G-CSF) treatment can improve the cognitive function of Alzheimer's disease (AD) mice, and the mobilized hematopoietic stem cells (HSCs) or bone marrow mesenchymal stem cells (BM-MSCs) are proposed to be involved in this recovery effect. However, the exact role of mobilized HSC/BM-MSC in G-CSF-based therapeutic effects is still unknown. Here, we report that C-X-C chemokine receptor type 4 (CXCR4)/stromal cell-derived factor 1 (SDF-1) chemotaxis was a key mediator in G-CSF-based therapeutic effects, which was involved in the recruitment of repair-competent cells. Furthermore, we found both mobilized HSCs and BM-MSCs were able to infiltrate into the brain, but only BM-MSCs replenished the neural lineage cells and contributed to neurogenesis in the brains of AD mice. Together, our data show that mobilized BM-MSCs are involved in the replenishment of neural lineages following G-CSF treatment via CXCR4/SDF-1 chemotaxis and further support the potential use of BM-MSCs for further autogenically therapeutic applications. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 16% |
Researcher | 5 | 14% |
Student > Master | 5 | 14% |
Lecturer | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Other | 6 | 16% |
Unknown | 9 | 24% |
Readers by discipline | Count | As % |
---|---|---|
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Medicine and Dentistry | 6 | 16% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Neuroscience | 3 | 8% |
Psychology | 1 | 3% |
Other | 3 | 8% |
Unknown | 12 | 32% |