Title |
Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
|
---|---|
Published in |
Journal of Neuro-Oncology, March 2013
|
DOI | 10.1007/s11060-013-1084-8 |
Pubmed ID | |
Authors |
Johnny C. Akers, David Gonda, Ryan Kim, Bob S. Carter, Clark C. Chen |
Abstract |
Recent studies suggest both normal and cancerous cells secrete vesicles into the extracellular space. These extracellular vesicles (EVs) contain materials that mirror the genetic and proteomic content of the secreting cell. The identification of cancer-specific material in EVs isolated from the biofluids (e.g., serum, cerebrospinal fluid, urine) of cancer patients suggests EVs as an attractive platform for biomarker development. It is important to recognize that the EVs derived from clinical samples are likely highly heterogeneous in make-up and arose from diverse sets of biologic processes. This article aims to review the biologic processes that give rise to various types of EVs, including exosomes, microvesicles, retrovirus like particles, and apoptotic bodies. Clinical pertinence of these EVs to neuro-oncology will also be discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Netherlands | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | <1% |
Denmark | 3 | <1% |
United Kingdom | 3 | <1% |
Poland | 2 | <1% |
Brazil | 2 | <1% |
Netherlands | 1 | <1% |
Switzerland | 1 | <1% |
Canada | 1 | <1% |
France | 1 | <1% |
Other | 4 | <1% |
Unknown | 1146 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 203 | 17% |
Student > Master | 166 | 14% |
Student > Bachelor | 163 | 14% |
Researcher | 119 | 10% |
Student > Doctoral Student | 75 | 6% |
Other | 103 | 9% |
Unknown | 339 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 288 | 25% |
Agricultural and Biological Sciences | 197 | 17% |
Medicine and Dentistry | 110 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 46 | 4% |
Immunology and Microbiology | 41 | 4% |
Other | 127 | 11% |
Unknown | 359 | 31% |