Title |
Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics
|
---|---|
Published in |
Trends in Cancer, November 2016
|
DOI | 10.1016/j.trecan.2016.10.009 |
Pubmed ID | |
Authors |
Xiaonan Zhang, Angelo De Milito, Asuman Demiroglu-Zergeroglu, Joachim Gullbo, Padraig D’Arcy, Stig Linder |
Abstract |
The presence of quiescent cell populations in solid tumors represents a major challenge for disease eradication. Such cells are generally present in poorly vascularized tumor areas, show limited sensitivity to traditional chemotherapeutical drugs, and tend to resume proliferation, resulting in tumor reseeding and growth. There is growing recognition of the importance of developing therapies that target these quiescent cell populations to achieve long-lasting remission. Recent studies have shown that the combination of hypoxia and reduced nutrient availability in poorly vascularized areas results in limited tumor metabolic plasticity coupled with an increased sensitivity to perturbations in mitochondrial flux. Targeting of mitochondrial bioenergetics in these quiescent cell tumor populations may enable tumor eradication and improve the prognosis of patients with cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Korea, Republic of | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 40% |
Scientists | 2 | 40% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 20% |
Researcher | 5 | 13% |
Student > Ph. D. Student | 5 | 13% |
Student > Doctoral Student | 4 | 10% |
Professor > Associate Professor | 3 | 8% |
Other | 5 | 13% |
Unknown | 10 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 23% |
Agricultural and Biological Sciences | 5 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
Medicine and Dentistry | 2 | 5% |
Engineering | 2 | 5% |
Other | 4 | 10% |
Unknown | 14 | 35% |