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Cell-associated HIV RNA: a dynamic biomarker of viral persistence

Overview of attention for article published in Retrovirology, April 2013
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 X user
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1 patent

Citations

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109 Dimensions

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212 Mendeley
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Title
Cell-associated HIV RNA: a dynamic biomarker of viral persistence
Published in
Retrovirology, April 2013
DOI 10.1186/1742-4690-10-41
Pubmed ID
Authors

Alexander O Pasternak, Vladimir V Lukashov, Ben Berkhout

Abstract

In most HIV-infected individuals adherent to modern antiretroviral therapy (ART), plasma viremia stays undetectable by clinical assays and therefore, additional virological markers for monitoring and predicting therapy responses and for measuring the degree of HIV persistence in patients on ART should be identified. For the above purposes, quantitation of cell-associated HIV biomarkers could provide a useful alternative to measurements of viral RNA in plasma. This review concentrates on cell-associated (CA) HIV RNA with the emphasis on its use as a virological biomarker. We discuss the significance of CA HIV RNA as a prognostic marker of disease progression in untreated patients and as an indicator of residual virus replication and the size of the dynamic viral reservoir in ART-treated patients. Potential value of this biomarker for monitoring the response to ART and to novel HIV eradication therapies is highlighted.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 212 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Germany 1 <1%
Belgium 1 <1%
Brazil 1 <1%
Spain 1 <1%
Denmark 1 <1%
Unknown 205 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 54 25%
Researcher 36 17%
Student > Master 28 13%
Student > Bachelor 17 8%
Student > Doctoral Student 16 8%
Other 28 13%
Unknown 33 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 45 21%
Medicine and Dentistry 41 19%
Immunology and Microbiology 39 18%
Biochemistry, Genetics and Molecular Biology 36 17%
Environmental Science 2 <1%
Other 8 4%
Unknown 41 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2020.
All research outputs
#6,925,375
of 22,707,247 outputs
Outputs from Retrovirology
#367
of 1,103 outputs
Outputs of similar age
#59,027
of 197,213 outputs
Outputs of similar age from Retrovirology
#11
of 17 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,213 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.