Title |
Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines
|
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Published in |
Chinese Medicine, July 2010
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DOI | 10.1186/1749-8546-5-26 |
Pubmed ID | |
Authors |
Stella Chai, Kenneth KW To, Ge Lin |
Abstract |
Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 3 | 3% |
Indonesia | 1 | <1% |
Chile | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 97 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 20 | 19% |
Student > Ph. D. Student | 16 | 16% |
Student > Bachelor | 16 | 16% |
Student > Doctoral Student | 10 | 10% |
Researcher | 8 | 8% |
Other | 14 | 14% |
Unknown | 19 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 21% |
Biochemistry, Genetics and Molecular Biology | 20 | 19% |
Medicine and Dentistry | 11 | 11% |
Chemistry | 9 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
Other | 11 | 11% |
Unknown | 22 | 21% |