To take this a step further, we identified genes whose expression is associated with risk for alcohol use, and then using an independent GWAS (https://t.co/WKWmTgkTWP) and data set of gene expression, replicated two of them. 8/10 https://t.co/GGo3M9fCIV
@StevePittelli @AmJPsychiatry @uk_biobank @23andMeResearch @mja @mcintosh2001 I believe the paywall is an error & will be made open access in due course. The replications were from various studies inc. Genetic Epidemiology Research in Adult Health and
RT @ethanjweiss: KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol prefer…
The relation of FGF21 to alcohol preference and as a feedback loops to sugar intake is interesting. Reminds me of the clinical observation that when heavy drinkers quit, their sweets craving increases. Complexity of this system may complicate therapeutic m