Title |
Peroral Endoscopic Myotomy for the Treatment of Achalasia: An International Prospective Multicenter Study
|
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Published in |
Gastroenterology, May 2013
|
DOI | 10.1053/j.gastro.2013.04.057 |
Pubmed ID | |
Authors |
Daniel Von Renteln, Karl–Hermann Fuchs, Paul Fockens, Peter Bauerfeind, Melina C. Vassiliou, Yuki B. Werner, Gerald Fried, Wolfram Breithaupt, Henriette Heinrich, Albert J. Bredenoord, Jan F. Kersten, Tessa Verlaan, Michael Trevisonno, Thomas Rösch |
Abstract |
Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months. |
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United States | 2 | 50% |
Saudi Arabia | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
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Chile | 1 | 1% |
Switzerland | 1 | 1% |
Unknown | 93 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 14 | 14% |
Researcher | 14 | 14% |
Student > Postgraduate | 10 | 10% |
Student > Doctoral Student | 9 | 9% |
Student > Ph. D. Student | 7 | 7% |
Other | 25 | 26% |
Unknown | 18 | 19% |
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Unspecified | 2 | 2% |
Biochemistry, Genetics and Molecular Biology | 2 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Environmental Science | 1 | 1% |
Other | 5 | 5% |
Unknown | 23 | 24% |