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Mendeley readers
Attention Score in Context
| Title |
Deep brain stimulation for obsessive–compulsive disorder is associated with cortisol changes
|
|---|---|
| Published in |
Psychoneuroendocrinology, January 2013
|
| DOI | 10.1016/j.psyneuen.2012.12.006 |
| Pubmed ID | |
| Authors |
Pelle P. de Koning, Martijn Figee, Erik Endert, Jitschak G. Storosum, Eric Fliers, Damiaan Denys |
| Abstract |
Deep brain stimulation (DBS) is an effective treatment for obsessive-compulsive disorder (OCD), but its mechanism of action is largely unknown. Since DBS may induce rapid symptomatic changes and the pathophysiology of OCD has been linked to the hypothalamic-pituitary-adrenal (HPA) axis, we set out to study whether DBS affects the HPA axis in OCD patients. We compared a stimulation ON and OFF condition with a one-week interval in 16 therapy-refractory OCD patients, treated with DBS for at least one year, targeted at the nucleus accumbens (NAc). We measured changes in 24-h urinary excretion of free cortisol (UFC), adrenaline and noradrenaline and changes in obsessive-compulsive (Y-BOCS), depressive (HAM-D) and anxiety (HAM-A) symptom scores. Median UFC levels increased with 53% in the OFF condition (from 93 to 143nmol/24h, p=0.12). There were no changes in urinary adrenaline or noradrenaline excretion. The increase in Y-BOCS (39%), and HAM-D (78%) scores correlated strongly with increased UFC levels in the OFF condition. Our findings indicate that symptom changes following DBS for OCD patients are associated with changes in UFC levels. |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| China | 1 | 1% |
| France | 1 | 1% |
| Unknown | 91 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 17% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Master | 14 | 15% |
| Researcher | 7 | 7% |
| Student > Doctoral Student | 5 | 5% |
| Other | 20 | 21% |
| Unknown | 18 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 31% |
| Psychology | 16 | 17% |
| Neuroscience | 10 | 11% |
| Agricultural and Biological Sciences | 6 | 6% |
| Philosophy | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 27 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2013.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Psychoneuroendocrinology
#3,465
of 3,904 outputs
Outputs of similar age
#261,591
of 292,943 outputs
Outputs of similar age from Psychoneuroendocrinology
#40
of 53 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,904 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,943 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.