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X Demographics
Mendeley readers
Attention Score in Context
| Title |
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
|
|---|---|
| Published in |
Genome Medicine, January 2017
|
| DOI | 10.1186/s13073-016-0393-x |
| Pubmed ID | |
| Authors |
Jianjiong Gao, Matthew T. Chang, Hannah C. Johnsen, Sizhi Paul Gao, Brooke E. Sylvester, Selcuk Onur Sumer, Hongxin Zhang, David B. Solit, Barry S. Taylor, Nikolaus Schultz, Chris Sander |
| Abstract |
Many mutations in cancer are of unknown functional significance. Standard methods use statistically significant recurrence of mutations in tumor samples as an indicator of functional impact. We extend such analyses into the long tail of rare mutations by considering recurrence of mutations in clusters of spatially close residues in protein structures. Analyzing 10,000 tumor exomes, we identify more than 3000 rarely mutated residues in proteins as potentially functional and experimentally validate several in RAC1 and MAP2K1. These potential driver mutations (web resources: 3dhotspots.org and cBioPortal.org) can extend the scope of genomically informed clinical trials and of personalized choice of therapy. |
X Demographics
The data shown below were collected from the profiles of 93 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 43 | 46% |
| United Kingdom | 7 | 8% |
| Australia | 3 | 3% |
| Singapore | 2 | 2% |
| Italy | 2 | 2% |
| Spain | 2 | 2% |
| France | 1 | 1% |
| Belgium | 1 | 1% |
| Austria | 1 | 1% |
| Other | 5 | 5% |
| Unknown | 26 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 48 | 52% |
| Members of the public | 39 | 42% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
| Practitioners (doctors, other healthcare professionals) | 3 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 213 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| United Kingdom | 1 | <1% |
| Sweden | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 208 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 25% |
| Researcher | 42 | 20% |
| Student > Master | 23 | 11% |
| Student > Bachelor | 18 | 8% |
| Other | 15 | 7% |
| Other | 31 | 15% |
| Unknown | 31 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 68 | 32% |
| Agricultural and Biological Sciences | 48 | 23% |
| Medicine and Dentistry | 19 | 9% |
| Computer Science | 15 | 7% |
| Nursing and Health Professions | 4 | 2% |
| Other | 21 | 10% |
| Unknown | 38 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 62. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2023.
All research outputs
#704,970
of 25,736,439 outputs
Outputs from Genome Medicine
#133
of 1,610 outputs
Outputs of similar age
#14,929
of 424,755 outputs
Outputs of similar age from Genome Medicine
#4
of 32 outputs
Altmetric has tracked 25,736,439 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,610 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,755 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.