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Amygdala activation and its functional connectivity during perception of emotional faces in social phobia and panic disorder

Overview of attention for article published in Journal of Psychiatric Research, April 2013
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Title
Amygdala activation and its functional connectivity during perception of emotional faces in social phobia and panic disorder
Published in
Journal of Psychiatric Research, April 2013
DOI 10.1016/j.jpsychires.2013.03.020
Pubmed ID
Authors

L.R. Demenescu, R. Kortekaas, H.R. Cremers, R.J. Renken, M.J. van Tol, N.J.A. van der Wee, D.J. Veltman, J.A. den Boer, K. Roelofs, A. Aleman

Abstract

Social phobia (SP) and panic disorder (PD) have been associated with aberrant amygdala responses to threat-related stimuli. The aim of the present study was to examine amygdala function and its connectivity with medial prefrontal cortex (mPFC) during emotional face perception in PD and SP, and the role of illness severity. Blood oxygen level dependent responses while perceiving emotional facial expressions were compared in 14 patients with PD, 17 patients with SP, 8 patients with comorbid PD and SP, and 16 healthy controls. We found that PD, but not SP, was associated with amygdala and lingual gyrus hypoactivation during perception of angry, fearful, happy and neutral faces, compared to healthy participants. No significant effect of PD and SP diagnoses was found on amygdala-mPFC connectivity. A positive correlation of anxiety symptom severity was found on amygdala-dorsal anterior cingulate and dorsal mPFC connectivity during perception of fearful faces. Amygdala hypoactivation suggests reduced responsiveness to positive and negative emotional faces in PD. Symptom severity, but not the presence of PD and SP diagnosis per se, explains most of the abnormalities in amygdala-mPFC connectivity during perception of fearful faces.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
Netherlands 2 2%
Chile 1 <1%
Unknown 113 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 25%
Researcher 16 14%
Student > Master 12 10%
Student > Bachelor 10 8%
Student > Doctoral Student 8 7%
Other 17 14%
Unknown 26 22%
Readers by discipline Count As %
Psychology 47 40%
Medicine and Dentistry 13 11%
Neuroscience 12 10%
Agricultural and Biological Sciences 6 5%
Nursing and Health Professions 2 2%
Other 8 7%
Unknown 30 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2013.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Journal of Psychiatric Research
#3,164
of 3,857 outputs
Outputs of similar age
#155,290
of 204,196 outputs
Outputs of similar age from Journal of Psychiatric Research
#31
of 41 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.