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Miltefosine Suppresses Inflammation in a Mouse Model of Inflammatory Bowel Disease

Overview of attention for article published in Inflammatory Bowel Diseases, June 2013
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Title
Miltefosine Suppresses Inflammation in a Mouse Model of Inflammatory Bowel Disease
Published in
Inflammatory Bowel Diseases, June 2013
DOI 10.1097/mib.0b013e3182917a2b
Pubmed ID
Authors

Auke P. Verhaar, Manon E. Wildenberg, Anje A. te Velde, Sybren L. Meijer, Anne Christine W. Vos, Marjolijn Duijvestein, Maikel P. Peppelenbosch, Daniel W. Hommes, Gijs R. van den Brink

Abstract

The repertoire of immunomodulators that can be used for the treatment of inflammatory bowel disease is limited. The use of these drugs is further restricted by the occurrence of side effects in a proportion of patients. Miltefosine (hexadecylphosphocholine) is a lipid drug developed in the 1980s for the treatment of cancer but is nowadays best known for its application in the oral treatment of leishmaniasis. Although the exact mechanism of action of miltefosine has yet to be elucidated, the drug has previously been shown to inhibit phospholipases and protein kinase C, both key components of proproliferative signal transduction in T cells.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 29%
Student > Master 5 29%
Student > Ph. D. Student 3 18%
Professor 2 12%
Other 1 6%
Other 0 0%
Unknown 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 29%
Pharmacology, Toxicology and Pharmaceutical Science 3 18%
Medicine and Dentistry 2 12%
Business, Management and Accounting 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 2 12%
Unknown 3 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2013.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Inflammatory Bowel Diseases
#3,115
of 3,731 outputs
Outputs of similar age
#156,675
of 206,477 outputs
Outputs of similar age from Inflammatory Bowel Diseases
#70
of 77 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,731 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,477 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.