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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D
|
|---|---|
| Published in |
Science, July 2013
|
| DOI | 10.1126/science.1240094 |
| Pubmed ID | |
| Authors |
Benjamin Chaigne-Delalande, Feng-Yen Li, Geraldine M. O’Connor, Marshall J. Lukacs, Ping Jiang, Lixin Zheng, Amber Shatzer, Matthew Biancalana, Stefania Pittaluga, Helen F. Matthews, Timothy J. Jancel, Jack J. Bleesing, Rebecca A. Marsh, Taco W. Kuijpers, Kim E. Nichols, Carrie L. Lucas, Sunil Nagpal, Huseyin Mehmet, Helen C. Su, Jeffrey I. Cohen, Gulbu Uzel, Michael J. Lenardo |
| Abstract |
The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium (Mg(2+)) concentrations. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg(2+) causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8(+) T cells and impairs cytolytic responses against EBV. Notably, magnesium supplementation in MAGT1-deficient patients restores intracellular free Mg(2+) and NKG2D while concurrently reducing EBV-infected cells in vivo, demonstrating a link between NKG2D cytolytic activity and EBV antiviral immunity in humans. Moreover, these findings reveal a specific molecular function of free basal intracellular Mg(2+) in eukaryotic cells. |
X Demographics
The data shown below were collected from the profiles of 53 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 21% |
| United Kingdom | 8 | 15% |
| Japan | 2 | 4% |
| France | 2 | 4% |
| Canada | 2 | 4% |
| Brazil | 2 | 4% |
| Turkey | 1 | 2% |
| Czechia | 1 | 2% |
| Bolivia, Plurinational State of | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 22 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 44 | 83% |
| Scientists | 6 | 11% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Spain | 1 | <1% |
| Germany | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 200 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 51 | 25% |
| Student > Ph. D. Student | 36 | 17% |
| Student > Master | 17 | 8% |
| Student > Bachelor | 14 | 7% |
| Other | 13 | 6% |
| Other | 47 | 23% |
| Unknown | 30 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 62 | 30% |
| Medicine and Dentistry | 43 | 21% |
| Immunology and Microbiology | 33 | 16% |
| Biochemistry, Genetics and Molecular Biology | 19 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Other | 13 | 6% |
| Unknown | 33 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2024.
All research outputs
#1,024,064
of 25,886,866 outputs
Outputs from Science
#19,042
of 83,398 outputs
Outputs of similar age
#8,247
of 207,950 outputs
Outputs of similar age from Science
#211
of 841 outputs
Altmetric has tracked 25,886,866 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,398 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.0. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,950 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 841 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.