Title |
Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)
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Published in |
PLoS Neglected Tropical Diseases, July 2013
|
DOI | 10.1371/journal.pntd.0002306 |
Pubmed ID | |
Authors |
Liesbeth M. Kager, Marcel Schouten, W. Joost Wiersinga, J. Daan de Boer, Lionel C. W. Lattenist, Joris J. T. H. Roelofs, Joost C. M. Meijers, Marcel Levi, Arjen M. Dondorp, Charles T. Esmon, Cornelis van 't Veer, Tom van der Poll |
Abstract |
The endothelial protein C receptor (EPCR) enhances anticoagulation by accelerating activation of protein C to activated protein C (APC) and mediates anti-inflammatory effects by facilitating APC-mediated signaling via protease activated receptor-1. We studied the role of EPCR in the host response during pneumonia-derived sepsis instigated by Burkholderia (B.) pseudomallei, the causative agent of melioidosis, a common form of community-acquired Gram-negative (pneumo)sepsis in South-East Asia. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | 3% |
Ethiopia | 1 | 3% |
Thailand | 1 | 3% |
Unknown | 34 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 14% |
Student > Master | 4 | 11% |
Student > Bachelor | 3 | 8% |
Researcher | 3 | 8% |
Other | 3 | 8% |
Other | 6 | 16% |
Unknown | 13 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 19% |
Biochemistry, Genetics and Molecular Biology | 6 | 16% |
Agricultural and Biological Sciences | 6 | 16% |
Immunology and Microbiology | 2 | 5% |
Decision Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 14 | 38% |