You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
The chromodomain helicase Chd4 is required for Polycomb‐mediated inhibition of astroglial differentiation
|
|---|---|
| Published in |
EMBO Journal, April 2013
|
| DOI | 10.1038/emboj.2013.93 |
| Pubmed ID | |
| Authors |
Anke Sparmann, Yunli Xie, Els Verhoeven, Michiel Vermeulen, Cesare Lancini, Gaetano Gargiulo, Danielle Hulsman, Matthias Mann, Juergen A Knoblich, Maarten van Lohuizen |
| Abstract |
Polycomb group (PcG) proteins form transcriptional repressor complexes with well-established functions during cell-fate determination. Yet, the mechanisms underlying their regulation remain poorly understood. Here, we extend the role of Polycomb complexes in the temporal control of neural progenitor cell (NPC) commitment by demonstrating that the PcG protein Ezh2 is necessary to prevent the premature onset of gliogenesis. In addition, we identify the chromodomain helicase DNA-binding protein 4 (Chd4) as a critical interaction partner of Ezh2 required specifically for PcG-mediated suppression of the key astrogenic marker gene GFAP. Accordingly, in vivo depletion of Chd4 in the developing neocortex promotes astrogenesis. Collectively, these results demonstrate that PcG proteins operate in a highly dynamic, developmental stage-dependent fashion during neural differentiation and suggest that target gene-specific mechanisms regulate Polycomb function during sequential cell-fate decisions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Denmark | 1 | <1% |
| China | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 125 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 27% |
| Researcher | 23 | 17% |
| Student > Master | 23 | 17% |
| Student > Bachelor | 10 | 8% |
| Professor | 8 | 6% |
| Other | 18 | 14% |
| Unknown | 15 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 63 | 47% |
| Biochemistry, Genetics and Molecular Biology | 34 | 26% |
| Neuroscience | 10 | 8% |
| Medicine and Dentistry | 7 | 5% |
| Nursing and Health Professions | 1 | <1% |
| Other | 3 | 2% |
| Unknown | 15 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2013.
All research outputs
#16,063,069
of 25,394,764 outputs
Outputs from EMBO Journal
#10,989
of 12,116 outputs
Outputs of similar age
#120,268
of 206,106 outputs
Outputs of similar age from EMBO Journal
#36
of 67 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,116 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,106 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.