Title |
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
|
---|---|
Published in |
Nature, August 1988
|
DOI | 10.1038/334676a0 |
Pubmed ID | |
Authors |
Christopher C. Goodnow, Jeffrey Crosbie, Stephen Adelstein, Thomas B. Lavoie, Sandra J. Smith-Gill, Robert A. Brink, Helen Pritchard-Briscoe, John S. Wotherspoon, Robert H. Loblay, Kathy Raphael, Ronald J. Trent, Antony Basten |
Abstract |
Immunological tolerance has been demonstrated in double-transgenic mice expressing the genes for a neo-self antigen, hen egg lysozyme, and a high affinity anti-lysozyme antibody. The majority of anti-lysozyme B-cells did not undergo clonal deletion, but were no longer able to secrete anti-lysozyme antibody and displayed markedly reduced levels of surface IgM while continuing to express high levels of surface IgD. These findings indicate that self tolerance may result from mechanisms other than clonal deletion, and are consistent with the hypothesis that IgD may have a unique role in B-cell tolerance. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 3 | <1% |
United States | 3 | <1% |
United Kingdom | 2 | <1% |
Switzerland | 1 | <1% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
Denmark | 1 | <1% |
Singapore | 1 | <1% |
Unknown | 339 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 92 | 26% |
Researcher | 57 | 16% |
Student > Bachelor | 34 | 10% |
Student > Master | 33 | 9% |
Student > Doctoral Student | 22 | 6% |
Other | 62 | 18% |
Unknown | 52 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 101 | 29% |
Immunology and Microbiology | 77 | 22% |
Medicine and Dentistry | 48 | 14% |
Biochemistry, Genetics and Molecular Biology | 46 | 13% |
Neuroscience | 4 | 1% |
Other | 20 | 6% |
Unknown | 56 | 16% |