Title |
Susac’s syndrome as HIV-associated immune reconstitution inflammatory syndrome
|
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Published in |
AIDS Research and Therapy, September 2013
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DOI | 10.1186/1742-6405-10-22 |
Pubmed ID | |
Authors |
Francesca Ferretti, Simonetta Gerevini, Bruno Colombo, Manuela Testa, Monica Guffanti, Diego Franciotta, Gaetano Bernardi, Adriano Lazzarin, Paola Cinque |
Abstract |
Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (cART). Corticosteroids and intravenous immunoglobulins alone did not control the disease, which improved after combined treatment with acyclovir and ganciclovir. SS onset in HIV infection and relapses during cART-induced immune reconstitution are consistent with the dysimmune nature of the disease. The response to anti-herpes drugs suggests a viral contribute in this case of SS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
South Africa | 1 | 2% |
Unknown | 44 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 15% |
Student > Bachelor | 6 | 13% |
Other | 5 | 11% |
Student > Doctoral Student | 5 | 11% |
Student > Ph. D. Student | 5 | 11% |
Other | 8 | 17% |
Unknown | 10 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 43% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Nursing and Health Professions | 3 | 7% |
Agricultural and Biological Sciences | 3 | 7% |
Immunology and Microbiology | 2 | 4% |
Other | 4 | 9% |
Unknown | 11 | 24% |