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Correlation between clinical symptoms and striatal DAT uptake in patients with DLB

Overview of attention for article published in Annals of Nuclear Medicine, March 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#19 of 635)
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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1 news outlet
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1 X user

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Title
Correlation between clinical symptoms and striatal DAT uptake in patients with DLB
Published in
Annals of Nuclear Medicine, March 2017
DOI 10.1007/s12149-017-1166-3
Pubmed ID
Authors

Soichiro Shimizu, Disuke Hirose, Nayuta Namioka, Hidekazu Kanetaka, Kentaro Hirao, Hirokuni Hatanaka, Naoto Takenoshita, Yoshitsugu Kaneko, Yusuke Ogawa, Takahiko Umahara, Hirofumi Sakurai, Haruo Hanyu

Abstract

It is widely known that there is low striatal (123)I-FP-CIT dopamine transporter-single photon emission tomography (DAT-SPECT) uptake in patients with dementia with Lewy bodies (DLB). We assessed the correlation between symptom and regional low DAT uptake in the striatum. Patients with Alzheimer's disease (AD) (n = 95) and patients with DLB (n = 133) who underwent DAT-SPECT were enrolled. We examined the correlation between symptoms [cognitive function decline, fluctuations, visual hallucinations, parkinsonism, and REM sleep behavior disorder (RBD)] and regional striatal DAT uptake in the patients with DLB. When comparing the DLB patients with or without fluctuations, visual hallucinations, or RBD, there were no significant differences in DAT uptake in any regions of the striatum. DLB patients with parkinsonism had significantly lower DAT uptake in entire striatum, entire putamen, and anterior putamen compared to DLB patients without parkinsonism. Moreover, there was weak but significant correlation between severity of parkinsonism and DAT uptake in entire regions of the striatum in patients with DLB. There was no significant correlation between cognitive function and DAT uptake in any regions of the striatum in patients with DLB. In patients with DLB, only parkinsonism is associated with a reduction in striatal DAT uptake.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 64 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 10 16%
Student > Ph. D. Student 9 14%
Researcher 9 14%
Student > Bachelor 5 8%
Other 5 8%
Other 8 13%
Unknown 18 28%
Readers by discipline Count As %
Unspecified 10 16%
Neuroscience 9 14%
Medicine and Dentistry 9 14%
Psychology 7 11%
Nursing and Health Professions 2 3%
Other 8 13%
Unknown 19 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2017.
All research outputs
#3,145,544
of 22,962,258 outputs
Outputs from Annals of Nuclear Medicine
#19
of 635 outputs
Outputs of similar age
#60,175
of 308,953 outputs
Outputs of similar age from Annals of Nuclear Medicine
#1
of 12 outputs
Altmetric has tracked 22,962,258 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 635 research outputs from this source. They receive a mean Attention Score of 2.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,953 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.