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The AG15693 Coriell sample from a 48 year old is annotated as "adult onset progeria" (aka Werner Syndrome), not HGPS as indicated in Fig 2T...
The AG15693 Coriell sample from a 48 year old is annotated as "adult onset progeria" (aka Werner Syndrome), not HGPS as indicated in Fig 2T...
Regarding your question: "Why dna methylation is related to chronological (and not biological) age?"Response by Steve Horvath: Actually, DNAm age relates to both chronological age and biological age...
As the author of the article, I thank you for your interest in Figure 2T. I checked the R code and the underlying data and they appear to be correct...
yes, it does look like there is a pretty old HGPS sample. A quick google search suggests that the oldest HGPS patient lived to be 29 years old...