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The relationship between microstructural alterations of the brain and clinical measurements in children and adolescents with hair pulling disorder

Overview of attention for article published in Brain Imaging and Behavior, March 2017
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Title
The relationship between microstructural alterations of the brain and clinical measurements in children and adolescents with hair pulling disorder
Published in
Brain Imaging and Behavior, March 2017
DOI 10.1007/s11682-017-9716-9
Pubmed ID
Authors

Geon Ho Bahn, Minha Hong, Kyung Mi Lee, Chanhee Lee, Chang-Woo Ryu, Ji-Ah Lee, Soonchan Park, Eui Jong Kim, Geon-Ho Jahng

Abstract

Several studies have evaluated gray matter abnormalities and white matter integrity in adults with hair pulling disorder (HPD). However, no prior studies have defined the relationship between neuroimaging parameters and clinical measurements in children and adolescents with HPD. The purposes of this study were to determine the correlation between magnetic resonance imaging (MRI) indices and clinical measurements in children and adolescents with HPD, and to compare HPD patients with age- and sex- matched healthy controls (HC). Pediatric HPD patients (n = 9) and HC subjects (n = 10), aged 9-17 years, were recruited. Three-dimensional T1-weighted structural MRI (3D T1W) and diffusion-tensor imaging (DTI) scans were obtained for each subject. Gray matter and white matter volumes were calculated from 3D T1W. Fractional anisotropy (FA) and average diffusion coefficients (Dav) were mapped from DTI. Voxel-based and region-of-interest correlations between MRI indices and clinical measurements were analyzed. In addition, two-sample t-tests were used to compare voxel-based tissue volumes, FA, and Dav maps between the two groups. Alterations in both brain tissue volume and white matter integrity were associated with symptom severity, especially in the precuneus, anterior cingulate, temporal cortex, and frontal cortex regions. FA values in HPD patients were significantly higher than those observed in HC subjects, particularly in the cerebellum and cuneus regions. Alterations of brain tissue volumes and microstructural changes are associated with severity of clinical symptoms in children and adolescents with HPD. Fractional anisotropy is the most sensitive method to distinguish pediatric HPD patients from healthy children. The results of this study can facilitate use of MRI indices to follow the transition from pediatric HPD to adult HPD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 13%
Student > Master 3 13%
Researcher 3 13%
Student > Doctoral Student 2 9%
Student > Postgraduate 2 9%
Other 3 13%
Unknown 7 30%
Readers by discipline Count As %
Neuroscience 5 22%
Psychology 3 13%
Social Sciences 2 9%
Medicine and Dentistry 2 9%
Engineering 1 4%
Other 0 0%
Unknown 10 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2017.
All research outputs
#20,412,387
of 22,962,258 outputs
Outputs from Brain Imaging and Behavior
#1,008
of 1,155 outputs
Outputs of similar age
#269,165
of 308,778 outputs
Outputs of similar age from Brain Imaging and Behavior
#29
of 39 outputs
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