Modeling of the human rhinovirus C capsid suggests a novel topography with insights on receptor preference and immunogenicity.

Overview of attention for article published in Virology, January 2014
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About this score

  • In the top 5% of all articles scored by Altmetric
  • One of the highest-scoring articles from this source (#1 of 1,438)
  • High score compared to articles of the same age (98th percentile)
  • High score compared to articles of the same age and source (95th percentile)

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mendeley
17 Mendeley
citeulike
1 CiteULike
Article title
Modeling of the human rhinovirus C capsid suggests a novel topography with insights on receptor preference and immunogenicity.
Published in
Virology, January 2014
DOI 10.1016/j.virol.2013.10.006
Pubmed ID
Authors

Holly A. Basta, Jean-Yves Sgro, Ann C. Palmenberg

Abstract

Features of human rhinovirus (RV)-C virions that allow them to use novel cell receptors and evade immune responses are unknown. Unlike the RV-A+B, these isolates cannot be propagated in typical culture systems or grown for structure studies. Comparative sequencing, I-TASSER, MODELLER, ROBETTA, and refined alignment techniques led to a structural approximation for C15 virions, based on the extensive, resolved RV-A+B datasets. The model predicts that all RV-C VP1 proteins are shorter by 21 residues relative to the RV-A, and 35 residues relative to the RV-B, effectively shaving the RV 5-fold plateau from the particle. There are major alterations in VP1 neutralizing epitopes and the structural determinants for ICAM-1 and LDLR receptors. The VP2 and VP3 elements are similar among all RV, but the loss of sequence "words" contributing Nim1ab has increased the apparent selective pressure among the RV-C to fix mutations elsewhere in the VP1, creating a possible compensatory epitope.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this article. Click here to see the article's page on the Mendeley website.

Geographical breakdown

Country Count As %
Australia 1 6%
United States 1 6%
Unknown 15 88%

Demographic breakdown

Readers by professional status Count As %
Ph.D. Student 4 24%
Student (Bachelor) 2 12%
Student (Master) 2 12%
Student (Postgraduate) 2 12%
Researcher (at an Academic Institution) 1 6%
Other 0 0%
Unknown 6 35%
Readers by discipline Count As %
Biological Sciences 7 41%
Chemistry 2 12%
Medicine 2 12%
Unknown 6 35%

Score in context

This article has an Altmetric score of 105. This is our high-level measure of the quality and quantity of online attention that this article has received. This score was calculated when the article was last mentioned on 09 January 2015.
All articles
#20,562
of 3,993,180 articles
Articles in Virology
#1
of 1,438 articles
Articles of similar age
#1,175
of 98,850 articles
Articles of similar age in Virology
#1
of 22 articles
Altmetric has tracked 3,993,180 articles across all sources so far. Compared to these this article has done particularly well and is in the 99th percentile: it's in the top 5% of all articles ever tracked by Altmetric.
So far Altmetric has tracked 1,438 articles from this source. They typically receive a little less attention than average, with a mean score of 2.9. This article has done particularly well, scoring higher than 99% of its peers.
Older articles will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this score to the 98,850 tracked articles that were published within six weeks on either side of this one in any source. This article has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this article to 22 articles from the same source and published within six weeks on either side of this one. This article has done particularly well, scoring higher than 95% of its contemporaries.