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Mendeley readers
Attention Score in Context
| Title |
Mechanisms of Hemagglutinin Targeted Influenza Virus Neutralization
|
|---|---|
| Published in |
PLOS ONE, December 2013
|
| DOI | 10.1371/journal.pone.0080034 |
| Pubmed ID | |
| Authors |
Boerries Brandenburg, Wouter Koudstaal, Jaap Goudsmit, Vincent Klaren, Chan Tang, Miriam V. Bujny, Hans J. W. M. Korse, Ted Kwaks, Jason J. Otterstrom, Jarek Juraszek, Antoine M. van Oijen, Ronald Vogels, Robert H. E. Friesen |
| Abstract |
Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved hemagglutinin (HA) epitopes of broadly neutralizing antibodies to critical processes in the viral life cycle. HA-stem binding antibodies can act intracellularly by blocking fusion between the viral and endosomal membranes and extracellularly by preventing the proteolytic activation of HA. HA-head binding antibodies prevent viral attachment and release. These insights into newly identified ways by which the human immune system can interfere with influenza virus infection may aid the development of novel universal vaccines and antivirals. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| United States | 1 | <1% |
| China | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 193 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 50 | 25% |
| Researcher | 38 | 19% |
| Student > Bachelor | 27 | 14% |
| Student > Master | 26 | 13% |
| Student > Doctoral Student | 8 | 4% |
| Other | 17 | 9% |
| Unknown | 31 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 23% |
| Biochemistry, Genetics and Molecular Biology | 37 | 19% |
| Immunology and Microbiology | 34 | 17% |
| Medicine and Dentistry | 12 | 6% |
| Chemistry | 10 | 5% |
| Other | 23 | 12% |
| Unknown | 36 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2023.
All research outputs
#2,033,533
of 23,342,092 outputs
Outputs from PLOS ONE
#25,851
of 199,597 outputs
Outputs of similar age
#24,324
of 310,077 outputs
Outputs of similar age from PLOS ONE
#695
of 5,305 outputs
Altmetric has tracked 23,342,092 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 199,597 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,077 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 5,305 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.