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Analysis of the Hydration Water around Bovine Serum Albumin Using Terahertz Coherent Synchrotron Radiation

Overview of attention for article published in Journal of Physical Chemistry A, December 2013
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Title
Analysis of the Hydration Water around Bovine Serum Albumin Using Terahertz Coherent Synchrotron Radiation
Published in
Journal of Physical Chemistry A, December 2013
DOI 10.1021/jp407410g
Pubmed ID
Authors

Jordan W. Bye, Stefano Meliga, Denis Ferachou, Gianfelice Cinque, J. Axel Zeitler, Robert J. Falconer

Abstract

Terahertz spectroscopy was used to study the absorption of bovine serum albumin (BSA) in water. The Diamond Light Source operating in a low alpha mode generated coherent synchrotron radiation that covered a useable spectral bandwidth of 0.3-3.3 THz (10-110 cm(-1)). As the BSA concentration was raised, there was a nonlinear change in absorption inconsistent with Beer's law. At low BSA concentrations (0-1 mM), the absorption remained constant or rose slightly. Above a concentration of 1 mM BSA, a steady decrease in absorption was observed, which was followed by a plateau that started at 2.5 mM. Using a overlapping hydration layer model, the hydration layer was estimated to extend 15 Å from the protein. Calculation of the corrected absorption coefficient (αcorr) for the water around BSA by subtracting the excluded volume of the protein provides an alternative approach to studying the hydration layer that provides evidence for complexity in the population of water around BSA.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
United States 1 <1%
Germany 1 <1%
Unknown 106 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 32 29%
Student > Ph. D. Student 26 24%
Student > Master 13 12%
Student > Bachelor 5 5%
Student > Postgraduate 5 5%
Other 14 13%
Unknown 15 14%
Readers by discipline Count As %
Physics and Astronomy 25 23%
Chemistry 20 18%
Engineering 10 9%
Biochemistry, Genetics and Molecular Biology 9 8%
Materials Science 6 5%
Other 14 13%
Unknown 26 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2013.
All research outputs
#20,674,485
of 25,394,764 outputs
Outputs from Journal of Physical Chemistry A
#5,883
of 10,503 outputs
Outputs of similar age
#244,948
of 320,598 outputs
Outputs of similar age from Journal of Physical Chemistry A
#52
of 124 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,503 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,598 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.