Title |
Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma
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Published in |
Digestive Diseases and Sciences, May 2017
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DOI | 10.1007/s10620-017-4615-x |
Pubmed ID | |
Authors |
Serena De Matteis, Anna Maria Granato, Roberta Napolitano, Chiara Molinari, Martina Valgiusti, Daniele Santini, Francesco Giuseppe Foschi, Giorgio Ercolani, Umberto Vespasiani Gentilucci, Luca Faloppi, Mario Scartozzi, Giovanni Luca Frassineti, Andrea Casadei Gardini |
Abstract |
Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD(+))-dependent type III histone deacetylases, are produced by cells to support in the defense against chronic stress conditions such as metabolic syndromes, neurodegeneration, and cancer. SIRT-3 is one of the most studied members of the mitochondrial sirtuins family. In particular, its involvement in metabolic diseases and its dual role in cancer have been described. In the present review, based on the evidence of SIRT-3 involvement in metabolic dysfunctions, we aimed to provide an insight into the multifaceted role of SIRT-3 in many solid and hematological tumors with a particular focus on hepatocellular carcinoma (HCC). SIRT-3 regulatory effect and involvement in metabolism dysfunctions may have strong implications in HCC development and treatment. Research literature widely reports the relationship between metabolic disorders and HCC development. This evidence suggests a putative bridge role of SIRT-3 between metabolic diseases and HCC. However, further studies are necessary to demonstrate such interconnection. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 25% |
Researcher | 5 | 21% |
Other | 2 | 8% |
Student > Bachelor | 2 | 8% |
Lecturer | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 17% |
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 13% |
Agricultural and Biological Sciences | 1 | 4% |
Engineering | 1 | 4% |
Other | 0 | 0% |
Unknown | 11 | 46% |