Title |
Refining the structure and content of clinical genomic reports
|
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Published in |
American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, March 2014
|
DOI | 10.1002/ajmg.c.31395 |
Pubmed ID | |
Authors |
Michael O Dorschner, Laura M Amendola, Brian H Shirts, Lesli Kiedrowski, Joseph Salama, Adam S Gordon, Stephanie M Fullerton, Peter Tarczy-Hornoch, Peter H Byers, Gail P Jarvik |
Abstract |
To effectively articulate the results of exome and genome sequencing we refined the structure and content of molecular test reports. To communicate results of a randomized control trial aimed at the evaluation of exome sequencing for clinical medicine, we developed a structured narrative report. With feedback from genetics and non-genetics professionals, we developed separate indication-specific and incidental findings reports. Standard test report elements were supplemented with research study-specific language, which highlighted the limitations of exome sequencing and provided detailed, structured results, and interpretations. The report format we developed to communicate research results can easily be transformed for clinical use by removal of research-specific statements and disclaimers. The development of clinical reports for exome sequencing has shown that accurate and open communication between the clinician and laboratory is ideally an ongoing process to address the increasing complexity of molecular genetic testing. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Israel | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 4 | 80% |
Members of the public | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 7 | 22% |
Student > Master | 6 | 19% |
Researcher | 5 | 16% |
Student > Doctoral Student | 3 | 9% |
Student > Postgraduate | 2 | 6% |
Other | 4 | 13% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 25% |
Medicine and Dentistry | 8 | 25% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Computer Science | 1 | 3% |
Social Sciences | 1 | 3% |
Other | 3 | 9% |
Unknown | 7 | 22% |