Title |
Early tissue responses to zoledronate, locally delivered by bone screw, into a compromised cancellous bone site: a pilot study
|
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Published in |
BMC Musculoskeletal Disorders, March 2014
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DOI | 10.1186/1471-2474-15-97 |
Pubmed ID | |
Authors |
Joerg Arnoldi, Antoine Alves, Philip Procter |
Abstract |
In fracture treatment, adequate fixation of implants is crucial to long-term clinical performance. Bisphosphonates (BP), potent inhibitors of osteoclastic bone resorption, are known to increase peri-implant bone mass and accelerate primary fixation. However, adverse effects are associated with systemic use of BPs. Thus, Zoledronic acid (ZOL) a potent BP was loaded on bone screws and evaluated in a local delivery model. Whilst mid- to long-term effects are already reported, early cellular events occurring at the implant/bone interface are not well described. The present study investigated early tissue responses to ZOL locally delivered, by bone screw, into a compromised cancellous bone site. |
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Mendeley readers
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Student > Master | 6 | 21% |
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