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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Global dissemination of a multidrug resistant Escherichia coli clone
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, March 2014
|
| DOI | 10.1073/pnas.1322678111 |
| Pubmed ID | |
| Authors |
Nicola K. Petty, Nouri L. Ben Zakour, Mitchell Stanton-Cook, Elizabeth Skippington, Makrina Totsika, Brian M. Forde, Minh-Duy Phan, Danilo Gomes Moriel, Kate M. Peters, Mark Davies, Benjamin A. Rogers, Gordon Dougan, Jesús Rodriguez-Baño, Alvaro Pascual, Johann D. D. Pitout, Mathew Upton, David L. Paterson, Timothy R. Walsh, Mark A. Schembri, Scott A. Beatson |
| Abstract |
Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a high proportion of urinary tract and bloodstream infections. The rapid emergence and successful spread of E. coli ST131 is strongly associated with several factors, including resistance to fluoroquinolones, high virulence gene content, the possession of the type 1 fimbriae FimH30 allele, and the production of the CTX-M-15 extended spectrum β-lactamase (ESBL). Here, we used genome sequencing to examine the molecular epidemiology of a collection of E. coli ST131 strains isolated from six distinct geographical locations across the world spanning 2000-2011. The global phylogeny of E. coli ST131, determined from whole-genome sequence data, revealed a single lineage of E. coli ST131 distinct from other extraintestinal E. coli strains within the B2 phylogroup. Three closely related E. coli ST131 sublineages were identified, with little association to geographic origin. The majority of single-nucleotide variants associated with each of the sublineages were due to recombination in regions adjacent to mobile genetic elements (MGEs). The most prevalent sublineage of ST131 strains was characterized by fluoroquinolone resistance, and a distinct virulence factor and MGE profile. Four different variants of the CTX-M ESBL-resistance gene were identified in our ST131 strains, with acquisition of CTX-M-15 representing a defining feature of a discrete but geographically dispersed ST131 sublineage. This study confirms the global dispersal of a single E. coli ST131 clone and demonstrates the role of MGEs and recombination in the evolution of this important MDR pathogen. |
X Demographics
The data shown below were collected from the profiles of 45 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 9 | 20% |
| United States | 8 | 18% |
| United Kingdom | 5 | 11% |
| India | 1 | 2% |
| Norway | 1 | 2% |
| Saudi Arabia | 1 | 2% |
| Saint Lucia | 1 | 2% |
| France | 1 | 2% |
| New Zealand | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 17 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 49% |
| Scientists | 18 | 40% |
| Science communicators (journalists, bloggers, editors) | 3 | 7% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 509 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | <1% |
| Germany | 2 | <1% |
| United States | 2 | <1% |
| United Kingdom | 2 | <1% |
| India | 2 | <1% |
| Denmark | 2 | <1% |
| Australia | 1 | <1% |
| France | 1 | <1% |
| Ecuador | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 491 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 87 | 17% |
| Student > Ph. D. Student | 83 | 16% |
| Student > Master | 64 | 13% |
| Student > Bachelor | 59 | 12% |
| Student > Doctoral Student | 33 | 6% |
| Other | 85 | 17% |
| Unknown | 98 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 129 | 25% |
| Biochemistry, Genetics and Molecular Biology | 83 | 16% |
| Immunology and Microbiology | 68 | 13% |
| Medicine and Dentistry | 46 | 9% |
| Veterinary Science and Veterinary Medicine | 15 | 3% |
| Other | 53 | 10% |
| Unknown | 115 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2019.
All research outputs
#581,442
of 25,736,439 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#10,013
of 103,638 outputs
Outputs of similar age
#5,070
of 240,139 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#150
of 1,002 outputs
Altmetric has tracked 25,736,439 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 103,638 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,139 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,002 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.