Title |
Obstructive sarcoidosis
|
---|---|
Published in |
Clinical Reviews in Allergy & Immunology, January 2003
|
DOI | 10.1385/criai:25:2:115 |
Pubmed ID | |
Authors |
Petey Laohaburanakit, Andrew Chan |
Abstract |
Sarcoidosis is a systemic granulomatous disease that frequently involves the lung. Although classically thought of as a restrictive lung disease, airway obstruction has become a recognized feature of the disease in the past years. Sarcoidosis can affect the airway at any level and when the involvement includes small airways, it can resemble more common obstructive airway diseases, such as asthma and chronic bronchitis. Pulmonary function testing and high-resolution computerized tomography of the chest are two important tools to evaluate the presence and extent of airway obstruction in sarcoidosis. Pharmacologic options for the treatment of obstructive sarcoidosis are, in large part, not supported by large, randomized clinical trials. In severe cases of bronchostenosis owing to sarcoidosis granuloma or extrinsic compression from intrathoracic lymphadenopathy, interventional bronchoscopy has successfully been performed, although repeated procedures are usually required. Lung transplantation is an ultimate option in selected patients with late-stage fibrotic disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 27% |
Other | 3 | 14% |
Student > Doctoral Student | 3 | 14% |
Student > Bachelor | 3 | 14% |
Student > Ph. D. Student | 2 | 9% |
Other | 3 | 14% |
Unknown | 2 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 50% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Computer Science | 1 | 5% |
Other | 3 | 14% |
Unknown | 4 | 18% |