Title |
Development of acute myeloid leukemia in patients with untreated chronic lymphocytic leukemia
|
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Published in |
Annals of Hematology, February 2017
|
DOI | 10.1007/s00277-017-2933-x |
Pubmed ID | |
Authors |
Shoko Ito, Shin-ichiro Fujiwara, Kiyomi Mashima, Kento Umino, Daisuke Minakata, Hirofumi Nakano, Ryoko Yamasaki, Yasufumi Kawasaki, Miyuki Sugimoto, Masahiro Ashizawa, Chihiro Yamamoto, Kaoru Hatano, Kiyoshi Okazuka, Kazuya Sato, Iekuni Oh, Ken Ohmine, Takahiro Suzuki, Kazuo Muroi, Yoshinobu Kanda |
Abstract |
The development of acute myeloid leukemia (AML) in patients with untreated chronic lymphocytic leukemia (CLL) is rare. We experienced a 65-year-old man who developed AML with aberrant CD7 expression and monoallelic CEBPA mutation during watchful waiting for CLL. He failed to achieve complete response (CR) by standard induction therapy for AML. We retrospectively reviewed 27 patients who developed AML with untreated CLL published between 1973 and 2016. The median age at diagnosis of AML was 68 years, and the median duration between the diagnoses of AML and CLL was 4.2 years. Diagnosis of AML and CLL was made simultaneously in 16 patients. The CR rate of AML was 42.9%, and the median survival was only 1.5 months after the diagnosis of AML. Patients who achieved CR tended to survive longer than those who did not. Our results demonstrated that the development of AML in patients with untreated CLL was associated with a poor response to chemotherapy and an extremely poor prognosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 13% |
Other | 2 | 9% |
Researcher | 2 | 9% |
Student > Doctoral Student | 1 | 4% |
Lecturer | 1 | 4% |
Other | 4 | 17% |
Unknown | 10 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 39% |
Nursing and Health Professions | 2 | 9% |
Computer Science | 1 | 4% |
Unknown | 11 | 48% |