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Mendeley readers
Attention Score in Context
| Title |
Th1 and Th2 immune response to P30 and ROP18 peptides in human toxoplasmosis
|
|---|---|
| Published in |
Medical Microbiology and Immunology, May 2014
|
| DOI | 10.1007/s00430-014-0339-0 |
| Pubmed ID | |
| Authors |
Elizabeth Torres-Morales, Laura Taborda, Nestor Cardona, Alejandra De-la-Torre, Juan Carlos Sepulveda-Arias, Manuel Alfonso Patarroyo, Jorge Enrique Gomez-Marin |
| Abstract |
We determined the specific lymphocyte proliferative response and cytokine profile production regarding Toxoplasma P30 (2017 from virulent and non-virulent strain) and ROP18 protein-derived peptides (from clonal lineages I, II and III) in 19 patients having ocular toxoplasmosis, five suffering chronic asymptomatic infection, nine with congenital toxoplasmosis and eight Toxoplasma negative people. A Beckman Coulter FC500 flow cytometer was used for determining antigen-specific T cells (CD3+ CD4+ or CD3+ CD8+ cells) in peripheral blood culture. IFN γ and IL10 levels were determined in culture supernatants. Specific CD4+ and CD8+ T cell response to total antigen and P30- and ROP18-derived peptides was observed in infected people. Ocular toxoplasmosis patients had a preferential Th2 response after antigenic stimulation. Non-virulent peptide 2017 was able to shift response toward Th1 in congenitally infected children and virulent peptide 2017 induced a Th2 response in chronically infected, asymptomatic people. An immune response in human toxoplasmosis after ex vivo antigenic stimulation was Th1- or Th2-skewed, depending on a patient's clinical condition. Colombian ocular toxoplasmosis patients' immune response was Th2-skewed, regardless of the nature of antigen stimulus. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 33% |
| United States | 1 | 33% |
| Armenia | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 20% |
| Student > Ph. D. Student | 8 | 14% |
| Researcher | 8 | 14% |
| Student > Master | 7 | 13% |
| Professor | 6 | 11% |
| Other | 12 | 21% |
| Unknown | 4 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 23% |
| Immunology and Microbiology | 10 | 18% |
| Medicine and Dentistry | 10 | 18% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Nursing and Health Professions | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 8 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2014.
All research outputs
#14,889,699
of 23,815,455 outputs
Outputs from Medical Microbiology and Immunology
#401
of 627 outputs
Outputs of similar age
#122,764
of 228,676 outputs
Outputs of similar age from Medical Microbiology and Immunology
#3
of 11 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 627 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,676 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.