Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2.

Overview of attention for article published in Biomaterials
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  • In the top 5% of all articles scored by Altmetric
  • One of the highest-scoring articles from this source (#4 of 1,343)
  • High score compared to articles of the same age (98th percentile)
  • High score compared to articles of the same age and source (98th percentile)

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Article title
Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2.
Published in
Biomaterials
DOI 10.1016/j.biomaterials.2014.05.011
Pubmed ID
Abstract

Biomaterials capable of providing localized and sustained presentation of bioactive proteins are critical for effective therapeutic growth factor delivery. However, current biomaterial delivery vehicles commonly suffer from limitations that can result in low retention of growth factors at the site of interest or adversely affect growth factor bioactivity. Heparin, a highly sulfated glycosaminoglycan, is an attractive growth factor delivery vehicle due to its ability to reversibly bind positively charged proteins, provide sustained delivery, and maintain protein bioactivity. This study describes the fabrication and characterization of heparin methacrylamide (HMAm) microparticles for recombinant growth factor delivery. HMAm microparticles were shown to efficiently bind several heparin-binding growth factors (e.g. bone morphogenetic protein-2 (BMP-2), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (FGF-2)), including a wide range of BMP-2 concentrations that exceeds the maximum binding capacity of other common growth factor delivery vehicles, such as gelatin. BMP-2 bioactivity was assessed on the basis of alkaline phosphatase (ALP) activity induced in skeletal myoblasts (C2C12). Microparticles loaded with BMP-2 stimulated comparable C2C12 ALP activity to soluble BMP-2 treatment, indicating that BMP-2-loaded microparticles retain bioactivity and potently elicit a functional cell response. In summary, our results suggest that heparin microparticles stably retain large amounts of bioactive BMP-2 for prolonged periods of time, and that presentation of BMP-2 via heparin microparticles can elicit cell responses comparable to soluble BMP-2 treatment. Consequently, heparin microparticles present an effective method of delivering and spatially retaining growth factors that could be used in a variety of systems to enable directed induction of cell fates and tissue regeneration.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this article. Click here to see the article's page on the Mendeley website.

Geographical breakdown

Country Count As %
Spain 2 20%
United States 1 10%
Unknown 7 70%

Demographic breakdown

Readers by professional status Count As %
Ph.D. Student 3 30%
Student (Master) 2 20%
Other Professional 1 10%
Researcher (at an Academic Institution) 1 10%
Post Doc 1 10%
Other 2 20%
Readers by discipline Count As %
Engineering 4 40%
Biological Sciences 2 20%
Medicine 2 20%
Materials Science 2 20%

Score in context

This article has an Altmetric score of 108.86. This is our high-level measure of the quality and quantity of online attention that this article has received. This score was calculated when the article was last mentioned on 30 October 2014.
All articles
#18,454
of 3,809,909 articles
Articles in Biomaterials
#4
of 1,343 articles
Articles of similar age
#1,104
of 94,559 articles
Articles of similar age in Biomaterials
#1
of 58 articles
Altmetric has tracked 3,809,909 articles across all sources so far. Compared to these this article has done particularly well and is in the 99th percentile: it's in the top 5% of all articles ever tracked by Altmetric.
So far Altmetric has tracked 1,343 articles from this source. They typically receive a little less attention than average, with a mean score of 3.9. This article has done particularly well, scoring higher than 99% of its peers.
Older articles will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this score to the 94,559 tracked articles that were published within six weeks on either side of this one in any source. This article has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this article to 58 articles from the same source and published within six weeks on either side of this one. This article has done particularly well, scoring higher than 98% of its contemporaries.