Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2.

Overview of attention for article published in Biomaterials
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  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#8 of 1,634)
  • High score compared to outputs of the same age (98th percentile)
  • High score compared to outputs of the same age and source (98th percentile)

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34 Mendeley
Title
Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2.
Published in
Biomaterials
DOI 10.1016/j.biomaterials.2014.05.011
Pubmed ID
Abstract

Biomaterials capable of providing localized and sustained presentation of bioactive proteins are critical for effective therapeutic growth factor delivery. However, current biomaterial delivery vehicles commonly suffer from limitations that can result in low retention of growth factors at the site of interest or adversely affect growth factor bioactivity. Heparin, a highly sulfated glycosaminoglycan, is an attractive growth factor delivery vehicle due to its ability to reversibly bind positively charged proteins, provide sustained delivery, and maintain protein bioactivity. This study describes the fabrication and characterization of heparin methacrylamide (HMAm) microparticles for recombinant growth factor delivery. HMAm microparticles were shown to efficiently bind several heparin-binding growth factors (e.g. bone morphogenetic protein-2 (BMP-2), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (FGF-2)), including a wide range of BMP-2 concentrations that exceeds the maximum binding capacity of other common growth factor delivery vehicles, such as gelatin. BMP-2 bioactivity was assessed on the basis of alkaline phosphatase (ALP) activity induced in skeletal myoblasts (C2C12). Microparticles loaded with BMP-2 stimulated comparable C2C12 ALP activity to soluble BMP-2 treatment, indicating that BMP-2-loaded microparticles retain bioactivity and potently elicit a functional cell response. In summary, our results suggest that heparin microparticles stably retain large amounts of bioactive BMP-2 for prolonged periods of time, and that presentation of BMP-2 via heparin microparticles can elicit cell responses comparable to soluble BMP-2 treatment. Consequently, heparin microparticles present an effective method of delivering and spatially retaining growth factors that could be used in a variety of systems to enable directed induction of cell fates and tissue regeneration.

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Mendeley readers

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Geographical breakdown

Country Count As %
United States 2 6%
Spain 1 3%
Unknown 31 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 15%
Unknown 29 85%
Readers by discipline Count As %
Biological Sciences 16 47%
Engineering 8 24%
Medicine 5 15%
Materials Science 4 12%
Computer and Information Science 1 3%
Other 0 0%

Score in context

This research output has an Altmetric score of 111. This is our high-level measure of the quality and quantity of online attention that it has received. This score was calculated when the research output was last mentioned on 30 October 2014.
All research outputs
#26,668
of 4,612,541 outputs
Outputs from Biomaterials
#8
of 1,634 outputs
Outputs of similar age
#1,356
of 106,982 outputs
Outputs of similar age from Biomaterials
#1
of 62 outputs
Altmetric has tracked 4,612,541 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,634 research outputs from this source. They receive a mean score of 4.5. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.