Title |
Gut microbiota and chronic kidney disease: implications for novel mechanistic insights and therapeutic strategies
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Published in |
Geriatric Nephrology and Urology, August 2017
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DOI | 10.1007/s11255-017-1689-5 |
Pubmed ID | |
Authors |
Wei Pan, Yongbo Kang |
Abstract |
The complicated communities of microbiota colonizing the human gastrointestinal tract exert a strong function in health maintenance and disease prevention. Indeed, accumulating evidence has indicated that the intestinal microbiota plays a key role in the pathogenesis and development of chronic kidney disease (CKD). Modulation of the gut microbiome composition in CKD may contribute to the accumulation of gut-derived uremic toxins, high circulating level of lipopolysaccharides and immune deregulation, all of which play a critical role in the pathogenesis of CKD and CKD-associated complications. In this review, we discuss the recent findings on the potential impact of gut microbiota in CKD and the underlying mechanisms by which microbiota can influence kidney diseases and vice versa. Additionally, the potential efficacy of pre-, pro- and synbiotics in the restoration of healthy gut microbia is described in detail to provide future directions for research. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 74 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 15% |
Student > Ph. D. Student | 10 | 14% |
Student > Bachelor | 9 | 12% |
Other | 6 | 8% |
Professor | 5 | 7% |
Other | 14 | 19% |
Unknown | 19 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 14% |
Biochemistry, Genetics and Molecular Biology | 8 | 11% |
Nursing and Health Professions | 4 | 5% |
Agricultural and Biological Sciences | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 15 | 20% |
Unknown | 29 | 39% |